The Bard of Avon: Shakespeare in Stratford-upon-Avon

These words were not all invented by Shakespeare but the earliest citations for them in the OED from Shakespeare.

Academe
accessible
accommodation
addiction ( meant “tendency”)
admirable
aerial ( meant “of the air”)
airless
amazement
anchovy
arch-villain
to arouse
assassination
auspicious
bachelorship (“bachelorhood”)
to barber
barefaced
baseless
batty (meant “bat-like”)
beachy (“beach-covered”)
to bedabble
to bedazzle
bedroom (meant “room in bed”)
to belly (“to swell”)
belongings
to besmirch
to bet
to bethump
birthplace
black-faced
to blanket
bloodstained
bloodsucking
blusterer
bodikins (“little bodies”)
bold-faced
braggartism
brisky
broomstaff (“broom-handle”)
bubble
budger (“one who budges”)
bump (as a noun)
buzzer (Meant “tattle-tale”)
to cake
candle holder
to canopy
to cater (as “to bring food”)
to castigate
catlike
to champion
characterless
cheap (in pejorative sense of “vulgar”)
chimney-top
chopped (Meant “chapped”)
churchlike
circumstantial
clutch
cold-blooded
coldhearted
colourful
compact (as noun “agreement”)
to comply
to compromise (Meant “to agree”)
consanguineous (related by blood)
control (as a noun)
coppernose (“a kind of acne”)
countless
courtship
to cow (as “intimidate”)
critical
cruelhearted
to cudgel
Dalmatian
to dapple
dauntless
dawn (as a noun)
day’s work
deaths-head
defeat (the noun)
to denote
depositary (as “trustee”)
dewdrop
dexterously (Shakespeare spelled it “dexteriously”)
disgraceful (Meant “unbecoming”)
to dishearten
to dislocate
distasteful (Meant “showing disgust”)
distrustful
dog-weary
doit (a Dutch coin: “a pittance”)
domineering
downstairs
East Indies
to educate
to elbow
embrace (as a noun)
employer
employment
enfranchisement
engagement
to enmesh
enrapt
to enthrone
epileptic
equivocal
eventful
excitement (Meant “incitement”)
expedience
expertness
exposure
eyeball
eyedrop (Meant as a “tear”)
eyewink
face (meaning the dial of a clock)
fair-faced
fairyland
fanged
fap (“intoxicated”)
farmhouse
far-off
fashionable
fashionmonger
fathomless (Meant “too huge to be encircled by one’s arms”)
fat-witted
featureless (Meant “ugly”)
fiendlike
to fishify (“turn into fish”)
fitful
fixture (Meant “fixing” or setting “firmly in place”)
fleshment (“the excitement of first success”)
flirt-gill (a “floozy”)
flowery (“full of florid expressions”)
fly-bitten
footfall
foppish
foregone
fortune-teller
foul mouthed
Franciscan
freezing (as an adjective)
fretful
frugal
full-grown
fullhearted
futurity
gallantry (Meant “gallant people”)
garden house
generous (Meant “gentle,” “noble”)
gentlefolk
glow (as a noun)
to glutton
to gnarl
go-between
to gossip (Meant “to make oneself at home like a gossip—that is, a kindred spirit or a fast friend”)
grass plot
gravel-blind
gray-eyed
green-eyed
grief-shot (as “sorrow-stricken”)
grime (as a noun)
to grovel
gust (as a “wind-blast”)
half-blooded
to happy (“to gladden”)
heartsore
hedge-pig
hell-born
to hinge
hint (as a noun)
hobnail (as a noun)
homely (sense “ugly”)
honey-tongued
hornbook (an “alphabet tablet”)
hostile
hot-blooded
howl (as a noun)
to humor
hunchbacked
hurly (as a “commotion”)
to hurry
idle-headed
ill-tempered
ill-used
impartial
to impede
imploratory (“solicitor”)
import (the noun: “importance” or “significance”)
inaudible
inauspicious
incarnadine (verb: "to make red with blood"; used in Macbeth)
indirection
indistinguishable
inducement
informal (Meant “unformed” or “irresolute”)
to inhearse (to “load into a hearse”)
to inlay
to instate (Shakespeare, who spelled it “enstate,” meant “to endow”)
inventorially (“in detail”)
investment (Meant as “a piece of clothing”)
invitation
invulnerable
jaded (Shakespeare seems to have meant “contemptible”)
juiced (“juicy”)
keech (“solidified fat”)
kickie-wickie (a derogatory term for a wife)
kitchen-wench
lackluster
ladybird
lament
land-rat
to lapse
laughable
leaky
leapfrog
lewdster
loggerhead (Meant “blockhead”)
lonely (Meant “lone”)
long-legged
love letter
lustihood
lustrous
madcap
madwoman
majestic
malignancy (Meant “malign tendency”)
manager
marketable
marriage bed
militarist (Meant “soldier”)
mimic (as a noun)
misgiving (sense “uneasiness”)
misquote
mockable (as “deserving ridicule”)
money’s worth (“money-worth” dates from the 14th century)
monumental
moonbeam
mortifying (as an adjective)
motionless
mountaineer (Meant as “mountain-dweller”)
to muddy
neglect (as a noun)
to negotiate
never-ending
newsmonger
nimble-footed
noiseless
nook-shotten (“full of corners or angles”)
to numb
obscene (Meant “revolting”)
ode
to offcap (to “doff one’s cap”)
offenseful (meaning “sinful”)
offenseless (“unoffending”)
Olympian (Meant “Olympic”)
to operate
oppugnancy (“antagonism”)
outbreak
to outdare
to outfrown
to out-Herod
to outscold
to outsell (Meant “to exceed in value”)
to out-talk
to out-villain
to outweigh
overblown (Meant “blown over”)
overcredulous
overgrowth
to overpay
to overpower
to overrate
overview (Meant as “supervision”)
pageantry
to palate (Meant “to relish”)
pale-faced
to pander
passado (a kind of sword-thrust)
paternal
pebbled
pedant (Meant a schoolmaster)
pedantical
pendulous (Meant “hanging over”)
to perplex
to petition
pignut (a type of tuber)
pious
please-man (a “yes-man”)
plumpy (“plump”)
posture (Shakespeare seems to have meant “position” or “positioning”)
prayerbook
priceless
profitless
Promethean
protester (Meant “one who affirms”)
published (Meant “commonly recognized”)
to puke
puppy-dog
pushpin (Shakespeare was referring to a children’s game)
on purpose
quarrelsome
in question (as in “the … in question”)
radiance
to rant
rascally
rawboned (meaning “very gaunt”)
reclusive
refractory
reinforcement (Meant “renewed force”)
reliance
remorseless
reprieve (as a noun)
resolve (as a noun)
restoration
restraint (as “reserve”)
retirement
to reverb (“to re-echo”)
revokement (“revocation”)
revolting (Meant as “rebellious”)
to reword (Meant “repeat”)
ring carrier (a “go-between”)
to rival (meaning to “compete”).
roadway
roguery
rose-cheeked
rose-lipped
rumination
ruttish (horny)
one's Salad Days
sanctimonious
to sate
satisfying (as an adjective)
savage (as “uncivilized”)
savagery
schoolboy
scrimer (“a fence”)
scrubbed (Meant “stunted”)
scuffle
seamy (“seamed”) and seamy-side (Meant “under-side of a garment”)
to secure (Meant “to obtain security”)
self-abuse (Meant “self-deception”)
shipwrecked (Shakespeare spelled it “shipwrackt”)
shooting star
shudder (as a noun)
silk stocking
silliness
to sire
skimble-skamble (“senseless”)
skim milk (in quarto; “skim’d milk” in the Folio)
slugabed (one who sleeps in)
to sneak
soft-hearted
spectacled
spilth (“something spilled”)
spleenful
sportive
to squabble
stealthy
stillborn
to subcontract (Meant “to remarry”)
successful
suffocating (as an adjective)
to sully
to supervise (Meant “to peruse”)
to swagger
tanling (someone with a tan)
tardiness
time-honored
title page
tortive (“twisted”)
to torture
traditional (Meant “tradition-bound”)
tranquil
transcendence
trippingly
unaccommodated
unappeased
to unbosom
unchanging
unclaimed
uncomfortable (sense “disquieting”)
to uncurl
to undervalue (Meant “to judge as of lesser value”)
to undress
unearthy
uneducated
to unfool
unfrequented
ungoverned
ungrown
to unhappy
unhelpful
unhidden
unlicensed
unmitigated
unmusical
to un muzzle
unpolluted
unpremeditated
unpublished (Meant “undisclosed”)
unquestionable (Meant “impatient”)
unquestioned
unreal
unrivaled
unscarred
unscratched
to unsex (verb: "to [in its context] make a woman unwomanly (that she might do deeds of men (murder)"; said by Lady Macbeth, in her husband's play)
unsolicited
unsullied
unswayed (Meant “unused” and “ungoverned”)
untutored
unvarnished
unwillingness (sense “reluctance”)
upstairs
useful
useless
valueless
varied (as an adjective)
varletry
vasty
vulnerable
watchdog
water drop
water fly
weird
well-behaved
well-bred
well-educated
well-read
to widen (Meant “to open wide”)
wittolly (“contentedly a cuckhold”)
worn out (Meant “dearly departed”)
wry-necked (“crook-necked”)
yelping (as an adjective)
zany (a clown’s sidekick or a mocking mimic)